OXELTIS

OXELTIS

CRO/CDMO

Created in 2010

21-50 employees

Your partner in Medicinal Chemistry and Life Sciences R&D

Many programs begin with strong biological findings but struggle to translate early hits, fragments, or tool compounds into viable lead candidates. This is often due to limited medicinal chemistry resources and insufficient insight into the challenges of advancing a lead toward a drug candidate and generating the data required to secure seed funding.

Oxeltis address this by:
• Seamless integration of in silico design (CADD, SBDD, LBDD, AI/ML) with high-quality synthesis, in partnership with Molecular Forecaster (Montreal) and Assay development/in vitro biological screening in partnership with Partex.AI.Labs
• Rapid hit-to-lead and lead optimization, with a track record of delivering high-quality compounds efficiently and a highly skill team of chemists (50% Ph.D., 50% M.Sc.)
• Expertise in complex and enabling chemistries, supported by our hybrid SFC platform for rapid purification and scale-up (up to 25g/day) of chiral/achiral mixtures.
• Comprehensive biological services, including assay design, in vitro screening, and early pharmacology profiling, integrated with chemistry to accelerate DMTA cycles and decision-making.

CONTACT INFORMATION

Christophe Parsy

Business & Strategic Development Director

Montpellier, France

parsy.christophe@oxeltis.com

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Enemsa Pharma

Enemsa Pharma

Pharma, Biotech

Created in 2026

1-5 employees

Redefining Treatment Through Synergy

Enemsa Pharma is a drug discovery company developing high‑impact combination therapies for intractable neurodegenerative and cardiopulmonary diseases—where monotherapies have failed. Inspired by breakthrough successes in oncology and infectious diseases, they target the untapped potential of multi‑mechanism approaches in complex disorders. Their strategy centers on modulating the Integrated Stress Response (ISR), a core cellular survival pathway implicated in many diseases.

Enemsa Pharma’s lead asset, icerguastat, is a clinically validated ISR modulator with Phase 1 completed. By sustaining the protective stress response, icerguastat prevents stress‑induced cell death and serves as a de‑risked backbone for first‑ or best‑in‑class synergistic combinations with approved or standard‑of‑care therapies. Their lead ongoing development program is icerguastat + ambroxol for Parkinson’s disease patients carrying GBA1 mutations, the most common genetic form of PD. This platform unlocks new IP, accelerates partnering, and aims to deliver transformative outcomes for patients with the highest unmet medical needs.

CONTACT INFORMATION

Pierre Miniou

CEO

Nantes, France

pminiou@enemsapharma.com

LinkedIn

ONCOVITA

ONCOVITA

Biotech

Series A – $20M to be raised

Created in 2015

6-10 employees

Unleashing the patient’s own power to fight cancer with a safe and effective vaccine

Oncovita, a Paris-based biotech spin-off from the Institut Pasteur, is developing a next-generation immunotherapy platform based on a genetically modified measles vaccine–derived virus. Its lead candidate, MVdeltaC, an « in situ » immunotherapy is in pre-IND development phase and will be first developped in two high unmet medical need diseases: Pleural Mesothelioma and in Triple Negative Breast Cancer.

CONTACT INFORMATION

Stéphane Altaba

CEO

Paris, France

stephane.altaba@oncovita.fr

LinkedIn

Vect-Horus

Vect-Horus

Biotech

Created in 2005

21-50 employees

Enhancing the transport of therapeutic and imaging agents using a versatile and flexible targeting technology

The VECTrans® technology exploits specific receptors selected for their high uptake/endocytosis and constitutive recycling capacity, thereby allowing significant intracellular transport and accumulation of therapeutic or imaging agents. Once the vector moiety of a vector-payload complex is locked onto the appropriate receptor at the surface of BBB endothelial cells, cancer cells or any target cell type expressing such receptors, the vector-payload complex undergoes rapid internalisation and subsequent intra/transcellular trafficking. This ultimately leads to payload delivery into cells and across the BBB into the brain via transport and transcytosis processes respectively thus modifying pharmacokinetic (PK) and distribution profile of therapeutic or imaging candidates.

CONTACT INFORMATION

Faustine Velasco Ramel

Senior Business Developer

Marseille, France

faustine.velasco@vect-horus.com

LinkedIn

Algenscribe

Algenscribe

Biotech

$1.9M raised

Created in 2022

1-5 employees

Reach the full potential of genome editing

Algenscribe is a pre-clinical stage biotechnology company developing a first-in-class Gene Replacement platform. The flexible platform aims to improve the efficiency and quality of Gene Editing from single bases to multi-kilobase replacements.

Algenscribe’s platform tackles technological challenges in gene editing:
1°) Boosts Efficiency: Dramatically increases gene replacement rates
2°) Enhances Precision: Minimizes nuclease-induced mutations
3°) Full-Scale Flexibility: Edits from single bases to multi-kilobase insertions
4°) Versatile Utility: Spans therapeutics and bioproduction
5°) Non-viral: Bypasses AAV-related delivery constraints.

CONTACT INFORMATION

Frédéric Zampatti

CEO

Nice, France

contact@algenscribe.com

LinkedIn

MAbSilico

MAbSilico

TechBio

$20M to be raised

Created in 2017

11-20 employees including 1-5 in the USA

20 days to design the best antibody candidates

MAbSilico is a premier TechBio company dedicated to developing and providing cutting-edge AI-based solutions for antibody drug design and discovery. They empower biotech and pharmaceutical companies to significantly leverage antibody discovery risks by providing high-potential computational candidates in just a matter of days. These candidates are meticulously designed and characterized in silico and subsequently validated with state-of-the-art biological technologies, ensuring a seamless transition from digital modeling to laboratory success. By combining sophisticated 3D modeling, complex interaction simulations, and advanced linear sequence analysis, MAbSilico defines antibody drug candidates through a rigorous assessment of their epitope, affinity, off-target risk, cross-species reactivity, and developability, ensuring they are fully prepared for biological activity evaluation.

Beyond their services, MAbSilico is advancing its own innovative discovery pipeline available for out-licensing, featuring high-quality leads in monoclonal, bispecific, and antibody-drug conjugate modalities. Their commitment to global innovation is reflected in an aggressive US development strategy, where they are actively seeking strategic partners to extend the deployment of their antibody design platform across the North American ecosystem. This international reach is further strengthened by their exclusive partnership with Yntoab to serve the Korean market and a landmark collaboration with Sartorius. The Sartorius partnership offers a comprehensive end-to-end solution that bridges the gap between lead candidate design and lead candidate production, including integrated cell line development to accelerate the path to clinical trials.

Furthermore, MAbSilico utilizes advanced NLP technologies to gather exhaustive information about antibodies and their targets from global databases, ensuring robust competitive landscape analysis and the freedom to operate for all computationally designed candidates. Through these integrated technologies and global alliances, MAbSilico transforms the traditional discovery process into a predictive, high-velocity engine for the next generation of immunotherapy.

CONTACT INFORMATION

Vincent Puard

CEO

Tours, France

vincent.puard@mabsilico.com

LinkedIn

Établissement Français du Sang

Établissement Français du Sang

Institution & Others

Created in 2000

500+ employees

Let’s Give Blood the Power to Heal

With 25 years of expertise in cell therapy, immunology and virology across fundamental, translational and clinical stages, Etablissement Français du Sang (EFS) combines strong capabilities in translational research, GMP-grade bioproduction and access to high-quality biological samples.

EFS operates four ATMP bioproduction platforms across France as a CDMO, supporting clinical manufacturing for a broad range of cell types including MSC, CAR-T, iPSC, hESC and HSC. EFS also performs the GMP manufacturing of cell banks (Master & Working) for its partners.

In addition, EFS has strenghten its offer, through its PIBT (Pôle d’Innovation en Biothérapies), a dedicated development platform, focused on the maturation of advanced therapy projects. This includes the evaluation and integration of innovative bioproduction technologies, process and analytical development, and scalability, with early consideration of manufacturing and GMP constraints.

Together, these capabilities provide a continuum from early-stage development to clinical production, enabling a smoother and more reliable transition toward industrialisation.

CONTACT INFORMATION

Célia Mercier

Business Development Manager

La Plaine Saint-Denis, France

Celia.Mercier@efs.sante.fr

LinkedIn

Ceres Brain Therapeutics

Ceres Brain Therapeutics

Biotech, Pharma

Series A – $20M to be raised

Created in 2019

6-10 employees

Rescuing neurons to treat brain diseases

Ceres Brain Therapeutics is a biotechnology company advancing CBT101, a novel central nervous system (CNS) therapeutic candidate that has recently progressed into Phase 2 clinical development. CBT101 is positioned to address major unmet needs in severe neurological diseases through a differentiated, indication specific approach to neuronal energy dysfunction.

CBT101 is being developed in amyotrophic lateral sclerosis (ALS), a rapidly progressive and fatal neurodegenerative disease with limited treatment options, as well as in creatine transporter deficiency (CTD), a rare paediatric neurological disorder with no effective disease modifying therapies. While based on a single molecular entity, CBT101 applies distinct mechanistic rationales aligned with each indication: targeting neuronal and mitochondrial energy dysfunction in ALS, and restoring intracellular creatine availability in neurons in CTD.

The program is supported by robust non clinical data and early clinical evidence demonstrating central nervous system activity and target engagement in humans. CBT101 is delivered as a non invasive nasal spray, offering a clear advantage in terms of patient convenience and treatment burden compared with injectable or hospital based therapies.

To support ongoing Phase 2 development and pipeline expansion, Ceres Brain Therapeutics is currently seeking to raise USD 20 million and is actively exploring strategic partnership opportunities, including co‑development, licensing, and regional collaborations, to accelerate development and maximize the value of CBT101 across its neurological indications.

CONTACT INFORMATION

Thomas Joudinaud

CEO

Paris, France

thomas.joudinaud@ceres-brain.com

LinkedIn

Diva Expertise

Diva Expertise

CRO/CDMO

Created in 2015

6-10 employees

The expert of studies and supply in human adipose tissue

DIVA Expertise is the leading global scientific partner for companies in the health, nutraceuticals and cosmetics industries seeking to evaluate the efficacy of an active ingredient or product directly on human adipose and skin tissue, ex vivo and in vitro. DIVA Expertise offers turnkey R&D projects – using unique, scientifically validated predictive human biological models – to provide industrial players with robust mechanistic evidence that accelerates and ensures the safe market launch of their innovations in cosmetics, nutraceuticals, and pharma metabolism/obesity.

What sets DIVA apart: DIVA biobank offering and innovative in vitro and ex vivo models enable preclinical expertise that closely aligns with the physiology of human adipose tissue, by working with real human biological materials from donors and adhering to the 3Rs principle (reduction of animal testing).

CONTACT INFORMATION

Sandra Robelet

Business Developer

Marseille, France

sandra.robelet@diva-expertise.com

LinkedIn

DeepLife

DeepLife

TechBio

Series A – $19M raised

Created in 2019

21-50 employees

Digital Twin of Cells for Drug Discovery

DeepLife is a techbio company advancing drug positioning through artificial intelligence and digital twins of human cell types.

Its platform, TwinCell, simulates cell-type-specific behaviour by integrating over 1 billion harmonized single-cell omics data points with causal AI, enabling more precise target identification, drug repositioning and disease understanding.

DeepLife applies this technology across autoimmune, neurodegenerative and cardio metabolic diseases among others. It partners with pharmaceutical and biotech companies on asset de-risking, indication expansion and disease relevant assessment. The company has established strategic collaborations including with Biersdorf in skin disease and aging.

DeepLife leverages cell-type-specific digital twin models to pinpoint the most relevant disease indications for any therapeutic compound. At the core is TwinCell – a large-scale causal model of cell biology that identifies the molecular drivers of disease and how to reverse them. TwinCell combines this insight with large scale single cell multi omics data to build precise models of human cell types and their regulatory networks.

These digital twins replicate real cellular behaviour, predicting preclinical outcomes and enabling researchers to explore disease mechanisms in silico. This approach uncovers how compounds act at the cell-type level, enhancing target validation, biomarker discovery and indication selection.

Applied across the drug development lifecycle, TwinCell accelerates decision making, reduces risk and improves translational relevance. It supports novel target discovery, asset de-risking, indication expansion and pipeline prioritization through strategic collaborations with pharmaceutical and biotech partners.

CONTACT INFORMATION

Jonathan Baptista

CEO & Co-founder

Paris, France

jonathan.baptista@deeplife.co

LinkedIn