MAAT PHARMA

MAAT PHARMA

About the company

MaaT Pharma is the leading microbiome company in oncology.
The Company owns in-house cGMP manufacturing capacities and specializes in developing Microbiome Ecosystem Therapies dedicated to enhancing the survival of cancer patients, with a focus on treating and preventing complications in blood cancers and improving treatments in immuno-oncology.

About the solution

MaaT013, a pooled-donor microbiome ecosystem therapy, is a non-immunosuppressive treatment dedicated to treat acute GvHD.
As of today, MaaT013 has been administered to more than 200 patients.
A Phase 3 trial is currently ongoing with ORR results expected in mid-2024.
The Company has an open-IND granted by the U.S. FDA and has engaged active discussions with prominent US clinicians in the field of stem cell transplantation to explore the most efficient path forward to introduce MaaT013 to patients in the United States.
MaaT013 has been awarded Orphan Drug Designation by the U.S. Food and Drug Administration (FDA) and European Medicines Agency (EMA).

MaaT033, a donor-derived, high-richness, high-diversity oral Microbiome Ecosystem TherapyTM containing is currently ongoing Phase 2 as an adjunctive therapy to improve overall survival in patients receiving HSCT and other cellular therapies.
MaaT033 has been granted Orphan Drug Designation by the European Medicines Agency (EMA) in August 2023.

Key information

– Therapeutic areas: Oncology, Hemato-Oncology: acute Graft-versus-Host Disease (aGvHD), allogenic hematopoietic stem cell transplantation; Immuno-oncology: metastatic melanoma; Neurodegenerative diseases : Amyotrophic lateral sclerosis (ALS).

– Based in: Lyon (FRANCE)

– Employees: 51-200

– Created in: 2014

CARTHERA

CARTHERA

About the company

Carthera is a clinical-stage company developing the SonoCloud, a revolutionary system to temporarily open the blood-brain barrier (BBB), and to improve CNS bioavailability of small molecules, ASOs, mAbs and other therapeutics. By using SonoCloud, the therapeutic efficacy of new and existing therapies can be unlocked and harnessed to improve the treatment of a wide range of brain diseases.

About the solution

SonoCloud is an intracranial implant using low-intensity pulsed ultrasound (LIPU) to temporarily open the blood-brain barrier BBB before or after the injection of therapeutics. This innovative approach is being tested in several clinical programs in Glioblastoma with different chemotherapeutic agents as well as PDL-1 & CTLA-4 antibodies. SonoCloud is now entering the neurodegeneration field with focus on ALS, Huntington Disease and Parkinson Disease.

Key information

–  Therapeutic areas: Oncology, Neurodegenerative diseases

–  Based in: Lyon (FRANCE) Office in Boston (USA)

–  Employees: 11 – 50

–  Created in: 2010

ALZPROTECT

ALZPROTECT

About the company

Alzprotect, established in 2007 in Lille, France, focuses on creating therapies to slow or halt neurodegenerative diseases and rejuvenate brain function. Alzprotect is dedicated to innovating in the neurodegenerative field. The company holds 4 international patent families for its developed drugs and their global indications.

About the solution

Alzprotect is making strides with AZP2006 (EZEPROGIND), a novel oral synthetic molecule aimed at enhancing lysosome homeostasis by regulating Progranulin and its chaperone protein, Prosaposin. Unlike traditional treatments that target symptoms like amyloid peptides or Tau protein, AZP2006 focuses on the root processes of neurodegeneration. It has shown promising results in reducing amyloid peptide secretion, lowering hyperphosphorylated Tau protein levels, and decreasing neuroinflammation, thus offering a comprehensive treatment approach. Granted « orphan drug » status in Europe and the US for Progressive Supranuclear Palsy (PSP), its safety and efficacy have been proven in human trials, paving the way for Phase 2B/3 trials for PSP and future applications in Parkinson’s disease, Alzheimer’s disease, and amyotrophic lateral sclerosis.

Key information

–  Therapeutic areas: Neurodegenerative diseases, Alzheimer’s disease, Progressive Nuclear Palsy, Parkinson’s disease

–  Based in: Loos (FRANCE), Boston (US)

–  Employees: 1 – 10

– Created in: 2007