IKTOS

IKTOS

About the company

Incorporated in October 2016, Iktos is a French start-up company specialized in the development of artificial intelligence solutions applied to chemical research, more specifically medicinal chemistry and new drug design.

Iktos is developing a proprietary and innovative solution based on deep generative models, which enables, using existing data, to design molecules that are optimized in silico to meet all the success criteria of a small molecule discovery project.

The use of Iktos technology enables major productivity gains in upstream pharmaceutical R&D. Iktos offers its technology through the SaaS software platforms Makya™ for generative drug design and Spaya™ for retrosynthesis, and through strategic collaborations with pharma companies where Iktos mobilizes its unique platform and leading-edge capabilities to expedite small molecule drug discovery for the benefit of its partners. Iktos is also developing Iktos Robotics, a unique AI-driven synthesis automation platform which dramatically accelerates the Design-Make-Test cycle in drug discovery.

About the solution

Iktos offers its technology through the SaaS software platforms Makya™ for generative drug design and Spaya™ for retrosynthesis, and through strategic collaborations with pharma companies where Iktos mobilizes its unique platform and leading-edge capabilities to expedite small molecule drug discovery for the benefit of its partners. Iktos is also developing Iktos Robotics, a unique AI-driven synthesis automation platform which dramatically accelerates the Design-Make-Test cycle in drug discovery.

Iktos offers the possiblity to its partners to use it unique technology via proprietary SaaS software platforms: Makya for de novo generative design and Spaya for retrosynthesis and synthetic access. Its partners can also rely on Iktos expertise to run integrated drug discovery projects from hit discovery, hit-to-lead, lead optimization, all the way down to preclinical drug candidate.

Key information

–  Therapeutic areas: Any therapeutic areas including oncology, CNS / neurology, Immunology, Infectious diseases, Rare diseases

–  Based in: Headquarters and lab: Paris (FRANCE)
Additional offices: US and JAPAN

–  Employees: 51 – 200

– Created in: 2016

CONTACT
Bose AvirupChief Business Officer

avirup.bose@iktos.com

EXELIOM BIOSCIENCES

EXELIOM BIOSCIENCES

About the company

Exeliom Biosciences is developing a new generation of immunotherapies based on therapeutic targets that play a critical role in our innate immunity.

About the solution

Their lead candidate, EXL01, is being currently evaluated in a Phase 1 clinical trial in Crohn’s disease, and in two Phase 2 clinical trials in gastric cancer in combination with FOLFOX and nivolumab, and in the prevention of recurrent C. difficile infection as an alternative to FMT. At least three additional Phase 2 trials in immune-oncology in combination with immune-checkpoint inhibitors and in postoperative Crohn’s disease are expected to start this year.
EXL01, a single-strain (F. prausnitzii) live biotherapeutic product, carries unique effectors promoting a distinct and potent immuno-modulatory signal. EXL01 also promotes antitumor efficacy of PD-L1 therapy and can be used in combination with immune-checkpoint inhibitors.

EXL01, is a NOD2 hyperagonist designed to activate macrophage and monocyte functions; notably to enhance immune-checkpoint inhibitors efficacy. It’s currently in 6 Phase II POC studies (Gastric, NSCLC, HCC & RCC, etc.)

Key information

–  Main industry type: Biotech

–  Therapeutic areas: Immuno-Oncology, Inflammatory Bowel Diseases, Infectious Diseases

–  Based in: Paris (France)

–  Employees: 1 – 10

– Created in: 2016

AQEMIA

AQEMIA

About the company

AQEMIA is a next-gen pharmatech company generating one of the world’s fastest-growing drug discovery pipeline. Their mission is to design fast innovative drug candidates for dozens of critical diseases.

About the solution

Their differentiation lies in their unique quantum and statistical mechanics algorithms fueling a generative artificial intelligence to design novel drug candidates, with already several drug discovery successes in internal pipeline as well as in collaboration with Pharma companies.

Key information

–  Therapeutic areas: Oncology, Immunology, Inflammation, Central Nervous System, Metabolism

–  Based in: Paris (FRANCE)

–  Employees: 51 – 200

– Created in: 2019