{"id":16972,"date":"2026-04-16T16:11:22","date_gmt":"2026-04-16T20:11:22","guid":{"rendered":"https:\/\/event.businessfrance.fr\/business-france-at-bio-convention\/?p=16972"},"modified":"2026-06-10T14:36:14","modified_gmt":"2026-06-10T18:36:14","slug":"hephaistos","status":"publish","type":"post","link":"https:\/\/event.businessfrance.fr\/business-france-at-bio-convention\/hephaistos\/","title":{"rendered":"HEPHAISTOS"},"content":{"rendered":"\n<div class=\"wp-block-getwid-section header-mobile alignfull getwid-margin-bottom-normal getwid-section-content-custom-width\"><div class=\"wp-block-getwid-section__wrapper getwid-padding-left-medium getwid-padding-right-medium\" style=\"min-height:350px\"><div class=\"wp-block-getwid-section__inner-wrapper\" style=\"max-width:740px\"><div class=\"wp-block-getwid-section__background-holder\"><div class=\"wp-block-getwid-section__background\" style=\"background-image:url('https:\/\/event.businessfrance.fr\/business-france-at-bio-convention\/wp-content\/uploads\/sites\/1378\/2026\/03\/5.png')\"><div class=\"wp-block-getwid-section__background-image-wrapper\"><img decoding=\"async\" class=\"wp-block-getwid-section__background-image\" src=\"https:\/\/event.businessfrance.fr\/business-france-at-bio-convention\/wp-content\/uploads\/sites\/1378\/2026\/03\/5.png\" alt=\"\"\/><\/div><\/div><div class=\"wp-block-getwid-section__foreground\"><\/div><\/div><div class=\"wp-block-getwid-section__content\"><div class=\"wp-block-getwid-section__inner-content\">\n<div class=\"wp-block-getwid-advanced-heading has-custom-font-size fs-mobile-60\" style=\"font-size:60px;margin-bottom:15px;margin-top:10px\"><h1 class=\"wp-block-getwid-advanced-heading__content has-text-color has-white-color\" style=\"text-align:center\">HEPHAISTOS<\/h1><\/div>\n<\/div><\/div><\/div><\/div><\/div>\n\n\n\n<div class=\"wp-block-getwid-section alignfull alignwide alignwide getwid-section-content-custom-width\" style=\"margin-bottom:0px\"><div class=\"wp-block-getwid-section__wrapper getwid-padding-left-medium getwid-padding-right-medium\" style=\"min-height:400px;padding-top:55px;padding-bottom:55px\"><div class=\"wp-block-getwid-section__inner-wrapper\" style=\"max-width:1140px\"><div class=\"wp-block-getwid-section__background-holder\"><div class=\"wp-block-getwid-section__background has-background has-dark-blue-background-color\"><\/div><div class=\"wp-block-getwid-section__foreground\"><\/div><\/div><div class=\"wp-block-getwid-section__content\"><div class=\"wp-block-getwid-section__inner-content\">\n<div class=\"wp-block-columns are-vertically-aligned-center is-layout-flex wp-container-core-columns-is-layout-8f761849 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\"><div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"512\" height=\"512\" src=\"https:\/\/event.businessfrance.fr\/business-france-at-bio-convention\/wp-content\/uploads\/sites\/1378\/2026\/03\/microscope.svg\" alt=\"\" class=\"wp-image-16552\" style=\"object-fit:cover;width:60px;height:60px\"\/><\/figure>\n<\/div>\n\n\n<p class=\"has-text-align-center wp-block-paragraph\">Biotech<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\"><div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full is-resized\"><img decoding=\"async\" src=\"https:\/\/event.businessfrance.fr\/next-healthcare-north-america\/wp-content\/uploads\/sites\/1377\/2026\/02\/inspiration.svg\" alt=\"\" class=\"wp-image-12630\" style=\"object-fit:cover;width:60px;height:auto\"\/><\/figure>\n<\/div>\n\n\n<p class=\"has-text-align-center wp-block-paragraph\">Created in 2018<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\"><div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full is-resized\"><img decoding=\"async\" src=\"https:\/\/event.businessfrance.fr\/next-healthcare-north-america\/wp-content\/uploads\/sites\/1377\/2026\/03\/employee.svg\" alt=\"\" class=\"wp-image-12755\" style=\"object-fit:cover;width:60px;height:60px\"\/><\/figure>\n<\/div>\n\n\n<p class=\"has-text-align-center wp-block-paragraph\">11-20 employees<\/p>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-columns are-vertically-aligned-center is-layout-flex wp-container-core-columns-is-layout-8f761849 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\"><div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"2094\" height=\"2093\" src=\"https:\/\/event.businessfrance.fr\/business-france-at-bio-convention\/wp-content\/uploads\/sites\/1378\/2026\/03\/Image3.png\" alt=\"\" class=\"wp-image-16135\" style=\"aspect-ratio:1.0005833625014584;width:136px;height:auto\" srcset=\"https:\/\/event.businessfrance.fr\/business-france-at-bio-convention\/wp-content\/uploads\/sites\/1378\/2026\/03\/Image3.png 2094w, https:\/\/event.businessfrance.fr\/business-france-at-bio-convention\/wp-content\/uploads\/sites\/1378\/2026\/03\/Image3-300x300.png 300w, https:\/\/event.businessfrance.fr\/business-france-at-bio-convention\/wp-content\/uploads\/sites\/1378\/2026\/03\/Image3-1024x1024.png 1024w, https:\/\/event.businessfrance.fr\/business-france-at-bio-convention\/wp-content\/uploads\/sites\/1378\/2026\/03\/Image3-150x150.png 150w, https:\/\/event.businessfrance.fr\/business-france-at-bio-convention\/wp-content\/uploads\/sites\/1378\/2026\/03\/Image3-768x768.png 768w, https:\/\/event.businessfrance.fr\/business-france-at-bio-convention\/wp-content\/uploads\/sites\/1378\/2026\/03\/Image3-1536x1536.png 1536w, https:\/\/event.businessfrance.fr\/business-france-at-bio-convention\/wp-content\/uploads\/sites\/1378\/2026\/03\/Image3-2048x2048.png 2048w, https:\/\/event.businessfrance.fr\/business-france-at-bio-convention\/wp-content\/uploads\/sites\/1378\/2026\/03\/Image3-938x938.png 938w, https:\/\/event.businessfrance.fr\/business-france-at-bio-convention\/wp-content\/uploads\/sites\/1378\/2026\/03\/Image3-1130x1129.png 1130w\" sizes=\"auto, (max-width: 2094px) 100vw, 2094px\" \/><\/figure>\n<\/div><\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\"><div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"422\" height=\"421\" src=\"https:\/\/event.businessfrance.fr\/business-france-at-bio-convention\/wp-content\/uploads\/sites\/1378\/2026\/03\/Image2.png\" alt=\"\" class=\"wp-image-15913\" style=\"width:118px;height:auto\" srcset=\"https:\/\/event.businessfrance.fr\/business-france-at-bio-convention\/wp-content\/uploads\/sites\/1378\/2026\/03\/Image2.png 422w, https:\/\/event.businessfrance.fr\/business-france-at-bio-convention\/wp-content\/uploads\/sites\/1378\/2026\/03\/Image2-300x300.png 300w, https:\/\/event.businessfrance.fr\/business-france-at-bio-convention\/wp-content\/uploads\/sites\/1378\/2026\/03\/Image2-150x150.png 150w\" sizes=\"auto, (max-width: 422px) 100vw, 422px\" \/><\/figure>\n<\/div><\/div>\n<\/div>\n<\/div><\/div><\/div><\/div><\/div>\n\n\n\n<div class=\"wp-block-getwid-section alignfull alignwide alignwide getwid-section-content-custom-width\" style=\"margin-bottom:0px\"><div class=\"wp-block-getwid-section__wrapper getwid-padding-left-medium getwid-padding-right-medium\" style=\"padding-top:55px;padding-bottom:55px\"><div class=\"wp-block-getwid-section__inner-wrapper\" style=\"max-width:1140px\"><div class=\"wp-block-getwid-section__background-holder\"><div class=\"wp-block-getwid-section__background has-background has-primary-background-color\"><\/div><div class=\"wp-block-getwid-section__foreground\"><\/div><\/div><div class=\"wp-block-getwid-section__content\"><div class=\"wp-block-getwid-section__inner-content\">\n<div class=\"wp-block-columns alignwide are-vertically-aligned-center is-layout-flex wp-container-core-columns-is-layout-8f761849 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-vertically-aligned-center is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:80%\">\n<div class=\"wp-block-getwid-advanced-heading alignfull alignfull has-custom-font-size fs-mobile-60\" style=\"font-size:40px;margin-bottom:3%;margin-top:10px\"><h3 class=\"wp-block-getwid-advanced-heading__content has-text-color has-dark-blue-color\" style=\"text-align:left\"><strong><mark style=\"background-color:#000091\" class=\"has-inline-color has-dark-blue-color\">Turn up the heat on cold tumors<\/mark><\/strong><\/h3><\/div>\n\n\n\n<div class=\"wp-block-buttons alignfull has-primary-background-color has-background is-horizontal is-content-justification-left is-layout-flex wp-container-core-buttons-is-layout-39697d9b wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button is-style-outline is-style-outline--1\"><a class=\"wp-block-button__link has-dark-blue-color has-primary-background-color has-text-color has-background has-link-color wp-element-button\" style=\"border-radius:0px\">Oncology<\/a><\/div>\n<\/div>\n\n\n\n<p class=\"wp-block-paragraph\"><mark style=\"background-color:#000091\" class=\"has-inline-color has-dark-blue-color\">HEPHAISTOS is a preclinical-stage biopharmaceutical company focused on designing and developing a third-generation innate immune activator. Its mission is to address a major challenge in oncology: improving patient responses to existing immunotherapies by overcoming myeloid-driven tumor immunosuppression.<\/mark><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><mark style=\"background-color:#000091\" class=\"has-inline-color has-dark-blue-color\">The company\u2019s lead candidate, HEPHA-440, enhances antitumor activity through multiple mechanisms. It promotes the recruitment of immune effector cells into the tumor microenvironment (TME), reverses macrophage polarization, activates dendritic cells and antigen presentation, and triggers CD8 T-cell\u2013mediated cytotoxicity.<\/mark><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><mark style=\"background-color:#000091\" class=\"has-inline-color has-dark-blue-color\">HEPHA-440 is an engineered small-molecule TLR4 agonist of the third generation. Compared to earlier clinical-stage compounds such as GLA and GSK1795091, it is 30 to 400 times safer, and it is twice as effective as first-generation molecules like GLA and MPL. It is also suitable for intravenous administration.<\/mark><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><mark style=\"background-color:#000091\" class=\"has-inline-color has-dark-blue-color\">Preclinical studies have shown that HEPHA-440 achieves a balanced MyD88\u2013TRIF signaling profile that favors antitumor cytokine production while maintaining low pyrogenicity. It has demonstrated strong single-agent efficacy, including complete tumor regressions and systemic effects against metastases. In combination therapies, it shows synergy with anti-PD-1 and anti-CD20 antibodies, achieving up to 100% complete tumor regression in some models. Additionally, it significantly increases PD-1 and PD-L1 expression within the tumor microenvironment.<\/mark><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><mark style=\"background-color:#000091\" class=\"has-inline-color has-dark-blue-color\">HEPHAISTOS has been awarded funding from the EIC Accelerator ($3 million) and the France 2030 RHU program ($11.5 million), and has also received recognition from Sanofi and Amgen through their Golden Ticket programs.<\/mark><\/p>\n<\/div>\n<\/div>\n<\/div><\/div><\/div><\/div><\/div>\n\n\n\n<div class=\"wp-block-getwid-section alignfull alignwide alignwide getwid-section-content-custom-width\" style=\"margin-bottom:0px\"><div class=\"wp-block-getwid-section__wrapper getwid-padding-left-medium getwid-padding-right-medium\" style=\"padding-top:55px;padding-bottom:55px\"><div class=\"wp-block-getwid-section__inner-wrapper\" style=\"max-width:1140px\"><div class=\"wp-block-getwid-section__background-holder\"><div class=\"wp-block-getwid-section__background has-background has-dark-blue-background-color\"><\/div><div class=\"wp-block-getwid-section__foreground\"><\/div><\/div><div class=\"wp-block-getwid-section__content\"><div class=\"wp-block-getwid-section__inner-content\">\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-8f761849 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-vertically-aligned-center is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:80%\">\n<div class=\"wp-block-getwid-advanced-heading alignwide alignwide has-custom-font-size fs-mobile-60\" style=\"font-size:40px;margin-bottom:3%;margin-top:10px\"><h3 class=\"wp-block-getwid-advanced-heading__content has-text-color\" style=\"text-align:left;color:#22242f\"><strong><mark style=\"background-color:#ffffff;color:#161616\" class=\"has-inline-color\">CONTACT INFORMATION<\/mark><\/strong><\/h3><\/div>\n\n\n\n<p class=\"has-medium-font-size wp-block-paragraph\"><strong><strong><strong><strong><strong>Fr\u00e9d\u00e9ric Caroff<\/strong><\/strong><\/strong><\/strong><\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">CEO<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Orsay, France<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">fc@hephaistos-pharma.com<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><a href=\"https:\/\/www.linkedin.com\/in\/frederic-caroff\/\">LinkedIn<\/a><\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-vertically-aligned-center is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:30%\"><div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"450\" height=\"450\" src=\"https:\/\/event.businessfrance.fr\/business-france-at-bio-convention\/wp-content\/uploads\/sites\/1378\/2026\/04\/Photo-Fred.jpg\" alt=\"\" class=\"wp-image-16988\" srcset=\"https:\/\/event.businessfrance.fr\/business-france-at-bio-convention\/wp-content\/uploads\/sites\/1378\/2026\/04\/Photo-Fred.jpg 450w, https:\/\/event.businessfrance.fr\/business-france-at-bio-convention\/wp-content\/uploads\/sites\/1378\/2026\/04\/Photo-Fred-300x300.jpg 300w, https:\/\/event.businessfrance.fr\/business-france-at-bio-convention\/wp-content\/uploads\/sites\/1378\/2026\/04\/Photo-Fred-150x150.jpg 150w\" sizes=\"auto, (max-width: 450px) 100vw, 450px\" \/><\/figure>\n<\/div><\/div>\n<\/div>\n<\/div><\/div><\/div><\/div><\/div>\n\n\n\n<div class=\"wp-block-getwid-section alignfull alignwide alignwide getwid-section-content-custom-width\" style=\"margin-bottom:0px\"><div class=\"wp-block-getwid-section__wrapper getwid-padding-left-medium getwid-padding-right-medium\" style=\"padding-top:55px;padding-bottom:55px\"><div class=\"wp-block-getwid-section__inner-wrapper\" style=\"max-width:1140px\"><div class=\"wp-block-getwid-section__background-holder\"><div class=\"wp-block-getwid-section__background has-background\" style=\"background-color:#e1f0fb\"><\/div><div class=\"wp-block-getwid-section__foreground\"><\/div><\/div><div class=\"wp-block-getwid-section__content\"><div class=\"wp-block-getwid-section__inner-content\">\n<div class=\"wp-block-getwid-advanced-heading alignwide alignwide has-custom-font-size fs-mobile-60\" style=\"font-size:40px;margin-bottom:3%;margin-top:10px\"><h3 class=\"wp-block-getwid-advanced-heading__content has-text-color has-primary-color\" style=\"text-align:center\"><strong><mark style=\"background-color:#e1f0fb\" class=\"has-inline-color has-primary-color\">DISCOVER MORE<\/mark><\/strong><\/h3><\/div>\n\n\n\n<div class=\"wp-block-columns are-vertically-aligned-center is-layout-flex wp-container-core-columns-is-layout-8f761849 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-vertically-aligned-center is-layout-flow wp-block-column-is-layout-flow\"><div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" src=\"https:\/\/event.businessfrance.fr\/nrf\/wp-content\/uploads\/sites\/1360\/2022\/05\/internet1.png\" alt=\"\" class=\"wp-image-10718\"\/><\/figure>\n<\/div>\n\n\n<div class=\"wp-block-buttons is-content-justification-center is-layout-flex wp-container-core-buttons-is-layout-fe48e5de wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button is-style-outline is-style-outline--2\"><a class=\"wp-block-button__link has-primary-color has-text-color has-link-color has-text-align-center has-small-font-size has-custom-font-size wp-element-button\" href=\"https:\/\/hephaistos-pharma.com\/\" style=\"border-radius:0px\">WEBSITE<\/a><\/div>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-vertically-aligned-center is-layout-flow wp-block-column-is-layout-flow\"><div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" src=\"https:\/\/event.businessfrance.fr\/nrf\/wp-content\/uploads\/sites\/1360\/2022\/05\/social-2.png\" alt=\"\" class=\"wp-image-10719\"\/><\/figure>\n<\/div>\n\n\n<div class=\"wp-block-buttons is-content-justification-center is-layout-flex wp-container-core-buttons-is-layout-fe48e5de wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button is-style-outline is-style-outline--3\"><a class=\"wp-block-button__link has-primary-color has-text-color has-link-color has-text-align-center has-small-font-size has-custom-font-size wp-element-button\" href=\"https:\/\/www.linkedin.com\/company\/hephaistos-pharma\/\" style=\"border-radius:0px\">hephaistos<\/a><\/div>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-vertically-aligned-center is-layout-flow wp-block-column-is-layout-flow\"><div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"512\" height=\"512\" src=\"https:\/\/event.businessfrance.fr\/business-france-at-bio-convention\/wp-content\/uploads\/sites\/1378\/2026\/03\/landing-page.svg\" alt=\"\" class=\"wp-image-16049\" style=\"width:92px;height:auto\"\/><\/figure>\n<\/div>\n\n\n<div class=\"wp-block-buttons is-content-justification-center is-layout-flex wp-container-core-buttons-is-layout-fe48e5de wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button is-style-outline is-style-outline--4\"><a class=\"wp-block-button__link has-primary-color has-text-color has-link-color has-text-align-center has-small-font-size has-custom-font-size wp-element-button\" href=\"https:\/\/event.businessfrance.fr\/business-france-at-bio-convention\/wp-content\/uploads\/sites\/1378\/2026\/05\/260522_exec-summary.pdf\" style=\"border-radius:0px\">ONe pager<\/a><\/div>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-vertically-aligned-center is-layout-flow wp-block-column-is-layout-flow\"><div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full is-resized\"><img decoding=\"async\" src=\"https:\/\/event.businessfrance.fr\/france-at-hlth\/wp-content\/uploads\/sites\/1440\/2025\/09\/catalogue.svg\" alt=\"\" class=\"wp-image-13677\" style=\"width:86px;height:auto\"\/><\/figure>\n<\/div>\n\n\n<div class=\"wp-block-buttons is-content-justification-center is-layout-flex wp-container-core-buttons-is-layout-fe48e5de wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button is-style-outline is-style-outline--5\"><a class=\"wp-block-button__link has-primary-color has-text-color has-link-color has-text-align-center has-small-font-size has-custom-font-size wp-element-button\" href=\"https:\/\/event.businessfrance.fr\/business-france-at-bio-convention\/wp-content\/uploads\/sites\/1378\/2026\/05\/260522_HEPHA_Deck.pdf\" style=\"border-radius:0px\">NON Confidential <br>company deck<\/a><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div><\/div><\/div><\/div><\/div>\n","protected":false},"excerpt":{"rendered":"<p>HEPHAISTOS is a preclinical-stage biopharmaceutical company focused on designing and developing a third-generation innate immune activator. 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